Comparative Study of Compartmental Modeling of Sustained Release Oral Dosage Forms and Intramuscular Injection
Abstract
This study has been performed to compare the compartmental modeling of two types of extravascular routes, sustained-release (SR) oral dosage forms and intramuscular (IM) injection. Twenty healthy volunteers received a single dose of 100 mg Diclofenac Sodium (DS) sustained-release tablet, then 75 mg DS Intramuscular injection after two weeks washout period. The concentrations of DS in plasma were measured using reverse-phase high-performance liquid chromatography (HPLC). The data analyzed using compartmental modeling, with single time-variant input and output. Primary kinetic parameters for both formulations, ( , , ) and other kinetic parameters were evaluated. The result shows that the IM injection needs a shorter time to reach the maximum concentration with convergent bioavailability to SR oral dosage forms, in another hand the data of IM injection fitted to single-compartment model with a correlation coefficient of 0.93 and the data of SR tablet fitted to two-compartment models with a correlation coefficient of 0.97.
Copyright (c) 2019 Al-Nahrain Journal for Engineering Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Author(s) Rights
- Each author retains the right to use the work for non-commercial purposes as well as for further research and spoken presentations.
- Each author retains the right to use the illustrations and research data in his/her future work.
- Only one offprint is provided free for each author. The authors can order offprints at the proof stage at certain rates depending on the number of additional copies required and the year of publication.
Publisher Rights
The publisher of the journal has all rights for publication in the paper, electronic and facsimile formats and for electronic capture, reproduction and licensing in all formats now and in perpetuity in the original and all derivative works.
