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Go to Editorial ManagerLately, nanotechnology has made significant advancements in various scientific and medical fields, including dentistry, by developing nanoparticles with distinct chemical and physical properties. Green synthesis is considered an eco-friendly alternative and a safe and sustainable method compared to conventional chemical and physical synthesis methods, which often contain toxic and environmentally harmful materials. This method is also cost-effective, biocompatible, and consumes less energy, thereby reducing pollution and environmental hazards, and making it suitable for various biomedical applications. Many nanoparticles have been employed in dentistry to enhance preventive treatments, including dental implants, orthodontics, the treatment of tooth decay bacteria, and endodontics. Despite their numerous benefits in the dental field, nanoparticles can exhibit toxicity risks, long-term impacts, and limited stability that require further investigation before their use in clinical applications. This review analyzes and classifies over 70 studies from the past 10 years based on plant extract source, nanoparticle types, and dental applications. We offer a new classification framework that organizes nanoparticles synthesized using green methods according to their manufacturing process and functional applications in dentistry. Comparative analysis reveals that, for instance, zinc oxide and silver nanoparticles synthesized through a green process exhibit the highest antibacterial activity with low toxicity. This review highlights current research gaps in biostability and toxicity, and provides insights into potential clinical applications and future research directions. It focuses on the role and benefits of the green method in improving the properties of nanoparticles, as well as its impact and effectiveness in developing dental materials and mitigating biological risks, opening up broad and new horizons in advanced dental treatments.
This study has been performed to compare the compartmental modeling of two types of extravascular routes, sustained-release (SR) oral dosage forms and intramuscular (IM) injection. Twenty healthy volunteers received a single dose of 100 mg Diclofenac Sodium (DS) sustained-release tablet, then 75 mg DS Intramuscular injection after two weeks washout period. The concentrations of DS in plasma were measured using reverse-phase high-performance liquid chromatography (HPLC). The data analyzed using compartmental modeling, with single time-variant input and output. Primary kinetic parameters for both formulations, ( , , ) and other kinetic parameters were evaluated. The result shows that the IM injection needs a shorter time to reach the maximum concentration with convergent bioavailability to SR oral dosage forms, in another hand the data of IM injection fitted to single-compartment model with a correlation coefficient of 0.93 and the data of SR tablet fitted to two-compartment models with a correlation coefficient of 0.97.
The process of placing the brackets in their proper positions in the field of orthodontics is consider one of the main steps in orthodontic treatment. In order to achieve high accuracy placements for the brackets, many methods are available today, starting from direct and indirect methods, each of them has advantages and disadvantages regarding the accuracy and the time for patient treatment. In this study, a new mechanism is introduce with its mechanical behavior in order to reduce the time required for patient treatment and to increase the accuracy for bracket placements. The newly mechanism was designed using Solidworks CAD software with a total Virtual functionality for all of the parts of the assembly, then a simulation was carried out to find the stress distribution, deformation, and strain on the main parts of the proposed assembly. The finished design shows a high precision mechanism that is able to place brackets one by one on the teeth.
Specimens with the structure of a face-centered cubic were produced using several sets of printing conditions. An experimental testing is conducted to carefully evaluate the microstructural analysis and compressive strength of this structure. The results include the measurement of mechanical properties, such as the peak stress. Fused deposition modeling is employed for the additive manufacturing of experimental specimens made from shape memory polymer thermoplastic polyurethane (MM-3520). We take into account the impact of printing factors on lattice structures, such as layer thickness, printing temperature, and printing speed. Analyzing the microstructure of the printed specimens exhibits that the specimens with highest printing temperature, lowest printing speed and thinner printing layer have better layers adhesion and lower porosities. All the mechanical tests are performed on specimens with the same structure and at a relatively constant density. Among the tested printing parameters, using a layer height of 0.1 mm, a printing temperature of 230 °C, and a printing speed of 20 mm/s yields the highest strength in the specimens. However, specimens printed with a layer height of 0.2 mm, a printing temperature of 220 °C, and a printing speed of 30 mm/s also exhibit good strength, albeit slightly lower than the maximum values. Additionally, when using these specific settings (0.3 mm – 210 °C – 40 mm/s), the mechanical qualities are minimized, yet the stress-strain curves exhibit characteristics similar to elastomers.
Functionally graded material is one of the promising sectors of the material since because of the great ability to control with required product properties could be strongly used in biomedical applications exclusively in the implants sector, this review paper demonstrates briefly about the most prominent known manufacturing methods and focusing on the implants coated by FGM layer manufactured by using EPD method because the EPD has significant properties it could produce FGM layer in the Room temperature without depending on chemical reactions or heat adding, Biomedical application need highly accuracy when we deal with material that directly contact with human tissue because the heat effect could be change the biocompatibility properties and also the chemical reactions could make toxic effect on the produced implants, All these reasons make the EPD one of the favorable method for the FGM coated Implants. this paper will summarise and give the Gide line for the researcher about the most important substrate and suspension materials used in the EPD method and its application.