Vol. 27 No. 1 (2024) Cover Image
Vol. 27 No. 1 (2024)

Published: March 31, 2024

Pages: 38-45

Articles

Review of Polymer Microfluidic Device Manufacturing Using Laser Technology

Safa N. Salman 1 Fatima H. Rajab 1 Ahmed A. Issa 2
1 Dept. of Laser and Optoelectronics Eng., College of Engineering, Al-Nahrain University, Baghdad, Iraq.
2 Mechatronics & Medical Devices Eng. Dept., Faculty of Engineering and Information Tech., Al Azhar University-Gaza.
History
  • Received: November 27, 2023
  • Revised: March 13, 2024
  • Accepted: April 5, 2024
  • Available Online: March 20, 2024
DOI

https://doi.org/10.29194/NJES.27010038

Abstract

This paper provides a comprehensive overview of microfluidic device (MFD) manufacturing processes. The review starts with an introduction elucidating the significance and advantages of MFDs. Subsequently, a brief description of the materials employed in MFD fabrication is presented. The manufacturing process used to create MFDs is then thoroughly examined, with a focus on the application of laser technology.

Keywords

References

  1. S. Solanki, C. M. Pandey, R. K. Gupta, and B. D. Malhotra, “Emerging trends in microfluidics based devices,” Biotechnol J, vol. 15, no. 5, p. 1900279, 2020.
  2. A. K. Yetisen, M. S. Akram, and C. R. Lowe, “based microfluidic point-of-care diagnostic devices,” Lab Chip, vol. 13, no. 12, pp. 2210–2251, 2013.
  3. W. K. Tomazelli Coltro, C. Cheng, E. Carrilho, and D. P. de Jesus, “Recent advances in low‐cost microfluidic platforms for diagnostic applications,” Electrophoresis, vol. 35, no. 16, pp. 2309–2324, 2014.
  4. J. P. Lafleur, A. Jönsson, S. Senkbeil, and J. P. Kutter, “Recent advances in lab-on-a-chip for biosensing applications,” Biosens Bioelectron, vol. 76, pp. 213–233, 2016.
  5. L. Lin and C.-K. Chung, “PDMS microfabrication and design for microfluidics and sustainable energy application,” Micromachines (Basel), vol. 12, no. 11, p. 1350, 2021.
  6. A. W. Martinez, S. T. Phillips, and G. M. Whitesides, “Devices (uPADs)-are a new platform designed for ASSURED,” Anal. Chem, vol. 82, pp. 3–10, 2010.
  7. A.-G. Niculescu, C. Chircov, A. C. Bîrcă, and A. M. Grumezescu, “Fabrication and applications of microfluidic devices: A review,” Int J Mol Sci, vol. 22, no. 4, p. 2011, 2021.
  8. J. Hwang, Y. H. Cho, M. S. Park, and B. H. Kim, “Microchannel fabrication on glass materials for microfluidic devices,” International Journal of Precision Engineering and Manufacturing, vol. 20, pp. 479–495, 2019.
  9. A. Singh, C. K. Malek, and S. K. Kulkarni, “Development in microreactor technology for nanoparticle synthesis,” Int J Nanosci, vol. 9, no. 01n02, pp. 93–112, 2010.
  10. Y. Song, J. Hormes, and C. S. S. R. Kumar, “Microfluidic synthesis of nanomaterials,” small, vol. 4, no. 6, pp. 698–711, 2008.
  11. M. James, R. A. Revia, Z. Stephen, and M. Zhang, “Microfluidic synthesis of iron oxide nanoparticles,” Nanomaterials, vol. 10, no. 11, p. 2113, 2020.
  12. J. B. Nielsen, R. L. Hanson, H. M. Almughamsi, C. Pang, T. R. Fish, and A. T. Woolley, “Microfluidics: innovations in materials and their fabrication and functionalization,” Anal Chem, vol. 92, no. 1, pp. 150–168, 2019.
  13. J. P. Martins, G. Torrieri, and H. A. Santos, “The importance of microfluidics for the preparation of nanoparticles as advanced drug delivery systems,” Expert Opin Drug Deliv, vol. 15, no. 5, pp. 469–479, 2018.
  14. V. Sebastián Cabeza, “Advances in microfluidics-New applications in biology, energy, and materials sciences. Chap 17: High and Efficient Production of Nanomaterials by Microfluidic Reactor Approaches,” IntechOpen, 2016.
  15. A. Ben Azouz, S. Murphy, S. Karazi, M. Vázquez, and D. Brabazon, “Fast fabrication process of microfluidic devices based on cyclic olefin copolymer,” Materials and Manufacturing Processes, vol. 29, no. 2, pp. 93–99, 2014.
  16. M. Vázquez, D. Brabazon, F. Shang, J. O. Omamogho, J. D. Glennon, and B. Paull, “Centrifugally-driven sample extraction, preconcentration and purification in microfluidic compact discs,” TrAC Trends in Analytical Chemistry, vol. 30, no. 10, pp. 1575–1586, 2011.
  17. V. Faustino, S. O. Catarino, R. Lima, and G. Minas, “Biomedical microfluidic devices by using low-cost fabrication techniques: A review,” J Biomech, vol. 49, no. 11, pp. 2280–2292, 2016.
  18. X. Yuan and R. D. Oleschuk, “Advances in microchip liquid chromatography,” Anal. Chem, vol. 90, no. 1, pp. 283–301, 2018.
  19. D.-K. Lee, J. Y. Kwon, and Y. H. Cho, “Fabrication of microfluidic channels with various cross-sectional shapes using anisotropic etching of Si and self-alignment,” Applied Physics A, vol. 125, pp. 1–7, 2019.
  20. M. Focke et al., “Microstructuring of polymer films for sensitive genotyping by real-time PCR on a centrifugal microfluidic platform,” Lab Chip, vol. 10, no. 19, pp. 2519–2526, 2010.
  21. B. S. Lee et al., “A fully automated immunoassay from whole blood on a disc,” Lab Chip, vol. 9, no. 11, pp. 1548–1555, 2009.
  22. M. Islam, R. Natu, and R. Martinez-Duarte, “A study on the limits and advantages of using a desktop cutter plotter to fabricate microfluidic networks,” Microfluid Nanofluidics, vol. 19, pp. 973–985, 2015.
  23. R. R. Gattass and E. Mazur, “Femtosecond laser micromachining in transparent materials,” Nat Photonics, vol. 2, no. 4, pp. 219–225, 2008.
  24. C. G. K. Malek, “Laser processing for bio-microfluidics applications (part I),” Anal. Bioanal. Chem., vol. 385, no. 8, pp. 1351–1361, 2006.
  25. M. Sparkes and W. M. Steen, “‘Light’ industry: an overview of the impact of lasers on manufacturing,” Advances in Laser Materials Processing, pp. 1–22, 2018.
  26. C. G. Khan Malek, “Laser processing for bio-microfluidics applications (part II),” Anal Bioanal Chem, vol. 385, pp. 1362–1369, 2006.
  27. C. G. Khan Malek, “Laser processing for bio-microfluidics applications (part I),” Anal Bioanal Chem, vol. 385, pp. 1351–1361, 2006.
  28. J. Choi and C. Schwarz, “Advances in femtosecond laser processing of optical material for device applications,” Int J Appl Glass Sci, vol. 11, no. 3, pp. 480–490, 2020.
  29. H. Wang, Y. Zhang, W. Wang, H. Ding, and H. Sun, “On‐chip laser processing for the development of multifunctional microfluidic chips (Laser Photonics Rev. 11 (2)/2017),” Laser Photon Rev, vol. 11, no. 2, p. 1770022, 2017.
  30. J. Schille, Investigation of micromachining using a high repetition rate femtosecond fibre laser. The University of Manchester (United Kingdom), 2013.
  31. Yiqiang Fan Huawei Li Ying Yi Ian G. Foulds, “Laser micromachined wax-covered plastic paper as both sputter deposition shadow masks and deep-ultraviolet patterning masks for polymethylmethacrylate-based microfluidic systems,” 2013.
  32. S. Prakash and S. Kumar, “Fabrication of microchannels on transparent PMMA using CO 2 Laser (10.6 μm) for microfluidic applications: An experimental investigation,” International Journal of Precision Engineering and Manufacturing, vol. 16, pp. 361–366, 2015.
  33. S. Prakash and S. Kumar, “CO2 laser microchanneling process: effects of compound parameters and pulse overlapping,” in IOP Conference Series: Materials Science and Engineering, IOP Publishing, 2016, p. 012018.
  34. S. Prakash and S. Kumar, “Fabrication of rectangular cross-sectional microchannels on PMMA with a CO2 laser and underwater fabricated copper mask,” Opt Laser Technol, vol. 94, pp. 180–192, 2017.
  35. A. Sen, B. Doloi, and ·B. Bhattacharyya, “Fibre Laser Microchanneling of Polymethyl Methacrylate (PMMA),” vol. 0, pp. 1–16, 2016.
  36. J. Cai et al., “Rapid prototyping of cyclic olefin copolymer based microfluidic system with CO 2 laser ablation,” Microsystem Technologies, vol. 23, pp. 5063–5069, 2017.
  37. C. Matellan and A. E. del Río Hernández, “Cost-effective rapid prototyping and assembly of poly (methyl methacrylate) microfluidic devices,” Sci Rep, vol. 8, no. 1, p. 6971, 2018.
  38. K. A. Hubeatir, M. M. Al-Kafaji, and H. J. Omran, “Deep engraving process of PMMA using CO2 laser complemented by Taguchi method,” in IOP Conference Series: Materials Science and Engineering, IOP Publishing, 2018, p. 012068.
  39. Yundong Ren, Subhrodeep Ray, and Yuxiang Liu, “Reconfgurable Acrylic-tape Hybrid Microfuidics,” 2019.
  40. Kexin Gao, Jingji Liu, Yiqiang Fan, and Yajun Zhang, “Ultra-low-cost fabrication of polymer-based microfluidic devices with diode laser ablation,” 2019.
  41. Mahdee Samae Pawarit Ritmetee Somyot Chirasatitsin Sanja Kojić Tijana Kojić · Jovana Jevremov Goran Stojanović Hani Al Salami, “Precise Manufacturing and Performance Validation of Paper Based Passive Microfuidic Micromixers,” 2019.
  42. G. M. S. and V. R. , Sanja P. Kojic, “Novel Cost-Effective Microfluidic Chip Based on Hybrid Fabrication and Its Comprehensive Characterization,” 2019.
  43. A. Sen, B. Doloi, and B. Bhattacharyya, “Parametric infuences of fber laser micro machining for the generation of micro channels on PMMA,” Jul. 2020.
  44. I. Bilican and M. T. Guler, “Assessment of PMMA and polystyrene based microfluidic chips fabricated using CO2 laser machining,” Appl Surf Sci, vol. 534, p. 147642, 2020.
  45. A. Farahinia and W. J. Zhang, “Numerical analysis of a microfluidic mixer and the effects of different cross-sections and various input angles on its mixing performance,” Journal of the Brazilian Society of Mechanical Sciences and Engineering, vol. 42, pp. 1–18, 2020.
  46. X. Hu, F. Yang, M. Guo, J. Pei, H. Zhao, and Y. Wang, “Fabrication of polyimide microfluidic devices by laser ablation based additive manufacturing,” Microsystem Technologies, vol. 26, pp. 1573–1583, 2020.
  47. P. R. Konari, Y.-D. Clayton, M. B. Vaughan, M. Khandaker, and M. R. Hossan, “Experimental analysis of laser micromachining of microchannels in common microfluidic substrates,” Micromachines (Basel), vol. 12, no. 2, p. 138, 2021.
  48. H. J. Imran, K. A. Hubeatir, and M. M. Al-Khafaji, “CO2 laser micro-engraving of PMMA complemented by Taguchi and ANOVA methods,” in Journal of Physics: Conference Series, IOP Publishing, 2021, p. 012062.
  49. I. Choi, S.-J. Lee, D. Shin, and J. Suh, “Green picosecond laser machining of thermoset and thermoplastic carbon fiber reinforced polymers,” Micromachines (Basel), vol. 12, no. 2, p. 205, 2021.
  50. A. Bonament, A. Prel, J.-M. Sallese, C. Lallement, and M. Madec, “Analytic modelling of passive microfluidic mixers,” Mathematical Biosciences and Engineering, vol. 19, no. 4, pp. 3892–3908, 2022.
  51. S. Gucluer and O. Guler, “A Low-Cost Laser-Prototyped Microfluidic Device for Separating Cells and Bacteria,” Applied Sciences, vol. 13, no. 13, p. 7938, 2023.